Andhra Pradesh is the leading and model aquaculture state in India. The aquaculture in the state has been recognized as a world class aquaculture site as it has witnessed all the three different phases of blue revolution. Inspite of the unprecedented development of diversified pond aquaculture in the state, in the recent times, many economically important problems have been persistently identified, which are threatening the sustainability of the culture systems ,like infectious diseases, feed, water quality problems and degraded quality of brood stock and seed. The solutions are need to be addressed, for the profitability and sustainability of the Fresh water Fish culture .