Pangas, Pangasianodon hypophthalmus commonly called as the world third most important freshwater cultivable species due to its fast growth and versatile feeding habit. In India, the inland fresh water cage culture is dominated by Pangasius. It was observed in many states that pangasius is being stocked @ 60-100/m3 in inland cages of reservoirs of India. However, the growth and survival of pangas is inversely proportional to stocking density and many farmers are also facing size differentiation at the above stocking densities. Addressing the above practical problem, the present study was conducted in order to know the effect of different stocking densities on the growth performance of pangas in cages in Salia reservoir of Odisha. Advanced fingerlings of pangas with an average weight of about 48.24±1.45 g were stocked in six different stocking densities viz. 20, 30, 40, 50 and 60 nos./m3 designated as T-1, T-2, T-3, T-4 and T-5. The experimental treatments were conducted in duplicate for a period of 240 days. The final weight (1225.12 ± 40.533 g), Specific growth rate (1.35 ± 0.016) and Survival (91.00 ± 2.646 %) were highest in lowest stocking density (20 nos./m3) whereas, the lowest growth was observed in highest stocking density (60 nos./m3). However, total fish biomass production was significantly (p<0.05) higher at the stocking density 30 to 40 nos./m3 and FCR was found lower in these two stocking densities. Therefore, the study suggest that the culture of pangas in lower stocking densities (30 to 40 nos./m3) can be consider as an optimum for the inland fresh water cage culture to reduce the feed and seed cost with higher growth and survival for maximization of economic return