Disease is the biggest unknown risk in Shrimp aquaculture, with a growing list of commercially devastating disease-causing pathogens around the world. Pathogen detection and screening has been fundamental to understand these pathogens, determine how to manage them during culture and develop successful Shrimp breeding programs. In recent times, the use of RNAi antivirals (double-stranded RNA injected into broodstock ) has also started to play a role in developing pathogen free breeding stocks. This presentation will describe some of the key ways in which pathogen detection, screening and RNAi antivirals are playing a role and being used in Shrimp Breeding and shrimp production globally. A short introduction to a high-throughput disease screening platform now on the market, Shrimp MultiPath, will also be given.