Tanzania is making significant strides in advancing sustainable aquaculture through the PROFISHBLUE Project (2022–2025) under the Southern African Development Community (SADC) framework, with support from the African Development Bank. This initiative is a pivotal contribution to the blue growth agenda, emphasizing sustainable fisheries management to bolster food security, economic resilience, and employment creation while strengthening intra-regional trade. With an integrated approach, the project enhances governance of shared fisheries and aquaculture resources, productivity, and market access by promoting value addition and empowering small and medium enterprises (SMEs) and cooperatives. Additionally, it prioritizes climate adaptation strategies, equipping fish value chain communities to withstand environmental changes and external shocks. Through regional collaboration, knowledge-sharing platforms, and data-driven decision-making, PROFISHBLUE fosters resilience and innovation. Implemented through a multi-stakeholder partnership, including SADC Member States, WorldFish, ARSO, FAO, UNIDO, and WWF Mozambique, the initiative exemplifies the interconnected objectives of fisheries and aquaculture sustainability, economic advancement, and regional trade integration. Key achievements include infrastructure modernization (refrigerated transport, vessel monitoring systems), governance capacity-building, SME development through exhibitions and e-commerce expansion, and the promotion of aquatic food products. Improved border hygiene facilities and emergency relief funding further safeguard the sector’s long-term stability. As Tanzania advances its aquaculture agenda, continued investment in policy harmonization, infrastructure enhancement, and capacity-building remains central to ensuring a lasting impact, reinforcing its role as a regional and global leader in sustainable aquaculture.