The study assessed the interactive effect of water temperature and nitrate fertilizers on growth, survival, and hatching success of eggs, embryos and larvae of African catfish Clarias gariepinus. One hundred fertilized eggs and 30 hatched larvae of C. gariepinus were incubated in glass flasks (1000ml) filled to 800ml mark with groundwater containing one of the five concentrations of inorganic nitrate (control, 5, 10, 15 and 20 mg NO3-N/L) levels. These flasks were randomly placed in three water bath each set at 25, 28, and 31ºC temperature levels in triplicates. Data were collected for ten days. The results showed a significant interaction between the temperature and nitrate on hatching rate, incubation period, hatching period for the egg and embryonic stages and the rate of growth and survival for the larval stage. C. gariepinus larvae were resilient to nitrate up to 10mg NO3-N/L at all incubation temperatures (28 to 31°C). The study concluded that the interaction between temperature and nitrate fertilizers had negative effects on the growth, survival and hatching success of C. gariepinus eggs, embryos and larvae. It is therefore recommended that alternative sources of nitrates such as organic farming should be encouraged in Agricultural fields other than artificial fertilizers.