Bioresilience® is defined as the fish’s ability to restore physiological balance, or allostasis, when facing environmental, sanitary, and production challenges that disrupt homeostasis. The use of functional mixtures based on algal extracts rich in fucans, botanical extracts with immunomodulatory activity, and standardized maqui berry extract with a high polyphenol content—which together provide the highest antioxidant capacity analyzed in a single product—favors an integrated response at multiple levels. At the systemic level, this results in the protection of target organs such as the liver, muscle, and heart, through the reduction of oxidative stress and the preservation of cellular bioenergetics.
Within the immune system, algal extracts enhance the phagocytic activity of macrophages and neutrophils, while botanical compounds regulate the transcription of inflammatory genes under NF-κB, limiting the overexpression of IL-1β and TNF-α and promoting a state of active anti-inflammation that resolves infection without compromising tissue integrity. In parallel, maqui polyphenols activate the Nrf2 pathway, promoting the expression of antioxidant enzymes (SOD, CAT, GPx) and reducing the accumulation of reactive oxygen species (ROS).
At the intestinal level, this combination supports the regeneration of villi, stimulates IgT production in mucosal tissues, improves colonization by beneficial bacteria, and promotes a microbiome profile with prebiotic properties. These effects translate into greater nutrient absorption capacity and stronger mucosal immunity. Altogether, these mechanisms improve animal welfare and enhance physiological efficiency, reflected in better feed conversion ratio (FCR), higher specific growth rate (SGR), and increased stock uniformity, contributing to the productive and sanitary sustainability of aquaculture.