Aquaponics integrates fish culture with soilless plant production (hydroponics), creating a symbiotic system in which fish waste provides nutrients for plants, while nitrifying bacteria convert ammonia into plant-available nitrates. Unlike hydroponics, where plants rely solely on nutrient-enriched water, aquaponics offers a closed-loop approach that enhances sustainability, conserves water, and supports local food production. This study evaluated the growth performance of Romaine lettuce (Lactuca sativa) and Channel catfish (Ictalurus punctatus) within an aquaponics system. Catfish were stocked under controlled conditions and fed daily at 3% of body weight, while Romaine lettuce seedlings were transplanted into a system supplied with reverse osmosis-treated water. Key water quality parameters—including ammonia, nitrite, nitrate, pH, dissolved oxygen, total dissolved solids (TDS), and electrical conductivity (EC)—were monitored regularly to optimize nutrient balance. Preliminary results showed that catfish achieved an average weight of 56.74 ± 15.71 g, while lettuce reached an average biomass of 17.76 ± 9.85 g, suggesting effective nutrient transfer and resource utilization. By combining fish and plant production, this aquaponic system demonstrates potential benefits for small-scale producers, including enhanced yields, reduced water consumption, and contributions to regional food security. Future research will compare these results with soil-based lettuce and pond-grown catfish to identify the most efficient and sustainable production strategies for leafy greens and fish.