Integrated Multi-Trophic Aquaculture (IMTA) aims to optimize sustainable aquaculture systems using complementary species from different trophic levels within a single system to enhance resource efficiency, environmental performance, and the availability of fresh, locally produced seafood. The first of its kind in the Gulf of America is in Alabama state waters and is designed to demonstrate feasibility for the northern Gulf. The path to demonstration included a comprehensive, multi-agency spatial planning, permitting, environmental monitoring, and community engagement exercise that selected a site with suitable biological characteristics and minimal user conflicts. Apart from engineering considerations for survival of the cage in the Gulf, operational considerations included selection of native species tolerant of prevailing environmental conditions with available culture technology and market value either recreationally or commercially. For this project, the graceful red weed (Gracilaria spp.), the eastern oyster (Crassostrea virginica), and the red drum (Sciaenops ocellatus) were selected as the producer, primary consumer, and secondary/tertiary consumer, respectively. A University of New Hampshire-developed floating raft called an AquaFort measuring 52 feet long and 28 feet wide containing two square net pens, each 20 feet long and 40 feet deep was used for this project. Organisms were cultured in recirculating systems under controlled conditions at the University of Southern Mississippi’s Thad Cochran Marine Aquaculture Center (TCMAC) in Ocean Springs, MS. Red drum broodstock were collected within 80 miles of the cage site, transported to TCMAC, sexed, quarantined, photothermally cycled, and spawned. Larvae were cultured using a variation of a standard red drum culture protocol that achieved an approximately 5-inch juvenile in 90 days. Oysters were produced from captive, local Gulf broodstock through temperature manipulation followed by an approximately 14-day larval rearing process in a recirculating system to produce pediveligers that were single set on microcultch and grown to an approximately R9 stage over 5 months. Graceful red weed collected in Gulf waters was isolated, quarantined, and vegetatively propagated in a recirculating system by manually dividing the tetrasporophyte phase and cultivating propagules in tumble tanks optimized for nutrients. Approximately 4000 juvenile red drum (40-60 g, 12-15 cm TL) were stocked in the AquaFort. Oysters and Macroalgae were stocked in Seapa® baskets suspended in arrays along the perimeter of the AquaFort at 12,000 R-9 and 6 g/L, respectively, and subdivided with growth. Estimated harvest after the first 8-month culture cycle is expected to be approximately 4000 kg of red drum, 4000-11,000 2-inch oysters, 8 kg of graceful red weed.