This study assessed the economic contributions of aquaculture in the U.S. Western Region through an integrated research–extension approach designed to meet industry and public needs for accurate, science-based information. Using detailed expenditure data from national and regional surveys of major aquaculture sectors—including shellfish, trout, tilapia, and sturgeon—researchers applied an Input–Output model via Impact Analysis for Planning to estimate economic output, employment, and tax impacts. Results indicate that commercial aquaculture farms generated $885.7 million in total economic output, supported over 6,000 jobs, and achieved multipliers of 1.90 for output and 1.39 for employment. Shellfish production accounted for the largest share ($360.6 million), followed by food fish for live and processing markets and recreational sales. To ensure accessibility and transparency, research findings were translated into extension-ready outputs, including a concise lay summary highlighting key economic metrics. This integration of rigorous economic modeling with clear, public-facing communication addressed a critical industry need: providing stakeholders, policymakers, and consumers with reliable, science-based insights into aquaculture’s role in regional economies. The coordinated research–extension framework strengthens informed decision-making, supports rural development, and enhances public understanding of aquaculture as a sustainable food system component.