Novel non-estrogenic endpoints of phenolic metabolites toxicity in fish: using zebra fish

Evidence of the severe effects of phenolic metabolites on different fish species exists in a number of axes including endocrine and non-endocrine as well. Regardless the classical issues of such metabolites as endocrine disrupting chemicals, novel non-estrogenic points are poorly studied. This article demonstrates the non-estrogenic attribution of certain phenolic metabolites  in fish species. Confirming this non-estrogenic action of such compounds, zebrafish (Danio rerio) embryos were subjected to different doses of Polybrominated diphenyl ethers (BDEs) to study the effect of such class of chemicals on the fish embryogenesis during the first 120 hours of fertilization.

Keywords Metabolites, Zebrafish, Toxicity, Endocrine Disruption