The American Soybean Association’s World Initiative for Soy in Human Health (ASA/WISHH) is leading efforts to strengthen agriculture value chains in emerging markets, creating trade and long-term demand for soy in sub-Saharan Africa. Through the support of the United States Department of Agriculture (USDA) and U.S. soybean farmers the program has expanded to include aquaculture value chain programs in Western Africa, with Nigeria, Ghana, and Senegal as the focus countries. One of the primary economic losses and inefficiencies in the value-chain is due to the losses associated with non-infectious and infectious diseases. Because of the complex interactions of the host-environment-pathogen relationship, ASA/WISHH’s partnership with producers, universities, and government agencies is providing training and field demonstration trials in underlying problems with production methods, water quality, diagnostics, diagnostic report interpretation and facilitating changes to farm management approaches to improve overall fish health and decrease mortalities. Example cases, problem approaches, and training will discussed.