A 30 days feeding trial was performed to investigate the effect of Sanacore® GM on the final growth, hematological indices, biochemical parameters, antioxidant response, immune status, and disease resistance of Nile tilapia . The fish were randomly distributed in two groups in triplicate and fed with Sanacore® GM at a dose of 5 gm/kg diet for a period of 30 days. At the end of the feeding trial, fish were challenged by Aeromonas veronii ( A. veronii ) and mortality rate was recorded for 15 days. The results showed that fish fed Sanacore® GM had significantly (P < 0.05) higher final weight than those fed control diet. Red blood cell, white blood cells, hemoglobin concentration, lymphocytes, and neutrophils were significantly increased in treated group . Serum total protein and albumin levels exhibited significant increase in treated group compared with control. In addition, the activity of antioxidant enzymes (superoxide dismutase and glutathione peroxidase ) revealed significant increase (P < 0.05) in Nile tilapia fed Sanacore ® GM supplemented diet . Meanwhile, Catalase activity recorded non-significant change (P > 0.05) among treate d and control groups. Sanacore ® GM supplemented group showed significant increase in immunological parameters ( phagocytic activity, serum bactericidal activity , lysozyme activity, IgM and nitric oxide levels). After A. veronii challenge, the survival rate was higher in treated group than the control (P < 0.05). The results of this study indicated that sanacore ® GM could significantly enhance growth, hemato -immunological parameters, antioxidant capability of Nile tilapia, as well as disease resistance against pathogenic strains of A. veronii .
Keywords : A. veronii, C ellular immunity, Feed additive, Hematology , Nile tilapia.