The shrimp diseases like the White spot syndrome virus (WSSV) and acute hepatopancreatic necrosis disease (AHPND) have appeared in almost all major shrimp-producing countries of South East Asia. Most of the available products in the market could not achieve the successful outcome as per expectation. A formulation was developed using blended essential oils as an anti-pathogen like, V. parahemolyticus and White Spot Syndrome Virus of shrimp. Vietnam is one of the significant suffering countries due to AHPND and was selected for the trial site. The formulation was first tested and optimized at Can Tho University and the Vietnam National University of Agriculture, Vietnam. The essential oil blend formulation (EOBF) was applied in the tanks before the challenge to the shrimp. Shrimp were challenged by V. parahemolyticus -AHPND strain, obtained from the University of Arizona, USA, after seven days of EOBF application. There was 100 % survival recorded in the EOBF applied groups, whereas 57 % cumulative mortality was recorded in the control groups. Similar results were obtained against the White sport syndrome virus. Later, field trials and observations were performed in several farms in the Quang Ninh , and Nam Dinh provinces of Vietnam using dose 0.4 ppm applied two times a week. The antimicrobial essential oil blend could significantly reduce the virulence of V. parahaemolyticus and WSSV in the shrimp ponds. The use of essential oil blend formulation resulted in better survival, growth, and productivity in the shrimp.