In intensive aquaculture systems oxygen supplementation is necessary to prevent hypoxia; however, oversupply can hyper-saturate systems causing gas bubble disease. Oxygenation in aquaculture systems using standard technologies is extremely inefficient; standard oxygen transfer efficiencies are estimated at between 2 and 6% per meter submergence for coarse and fine bubble diffusers, respectively, at standard conditions of 0 ppt salinity and 20 °C. Advances in the efficiency of gas–liquid phase processes has seen the emergence of nanobubble technologies producing ultrafine bubbles (? <1 µm). The advantage of nanobubbles over larger micro/macrobubbles is that they are neutrally buoyant, negatively charged and can remain within the water column, potentially for weeks. Nanobubble technologies now have a demonstrated application across a broad variety of industries including wastewater treatment, biomedical engineering, gas and oil industry, agriculture, and the food industry. Surprisingly, outside of Japan, there has been little research on the application of nanobubble technology to the aquaculture sector. Nanobubble technology can potentially improve oxygen delivery systems for fish stock and water treatment in aquaculture systems, improving the nitrifying capacity of biofilters and efficiencies in fractionation units. However, there are currently no reliable studies demonstrating the efficacy of nanobubble technology, nor any assessment of the potential health impacts on fish in aquaculture systems. We have undertaken a preliminary pilot trial with encouraging results. This project investigates the efficacy of nanobubble technology for use in finfish aquaculture by assessing the health, growth and feed conversion efficiencies of fish cultured in a recirculating aquaculture system at different temperatures, salinities and stocking densities exposed to nanobubbles.