Recirculating aquaculture systems have emerged as a key technology for sustainable and biosecure shrimp production, offering water reuse, improved disease control, and environmental compliance. However, the successful operation of shrimp RAS requires far more than the installation of advanced equipment. Many farms encounter performance instability, poor water quality, or inconsistent survival due to weak understanding of system integration, incorrect design assumptions, or inadequate daily management. A major weakness in many shrimp RAS operations begins before culture even starts, during the disinfection and preparation phase. Inefficient pond or tank disinfection leaves residual pathogen communities that quickly destabilize system water. Inadequate maintenance between production cycles also allows biofilm and sludge to accumulate within piping, sump tanks, and filters. These biofilms serve as reservoirs for opportunistic pathogens such as Vibrio spp., which can rapidly proliferate when environmental conditions fluctuate. Filters, aeration lines, and tank surfaces require thorough cleaning and drying to prevent biofilm hardening and pathogen persistence. During production, poor biosecurity planning and enforcement further compromise performance. Staff movement between tanks without proper disinfection, shared equipment across systems, and the absence of a clear “clean-to-dirty” workflow create continuous risks of cross-contamination. Shrimp RAS facilities require strict standard operating procedures that include quarantine of new post-larvae, regular sanitation of tools and nets, and dedicated water loops for different production stages. The system’s complexity magnifies the impact of even small oversights. Neglecting routine hygiene or skipping downtime maintenance can lead to rapid water quality deterioration and increased disease susceptibility. Ultimately, successful shrimp RAS operation depends on disciplined implementation of fundamental farm hygiene and biosecurity practices.