There is increasing number of evidence regarding how dietary interventions during the early stages of development can have long-term on the metabolism of different organisms, including fish . In the recent years, in commercially important fish species, it has been demonstrated the possibility of routing the metabolism for better usage of more sustainable formulated diets. In this review, the effects of early dietary interventions, focusing on improving the utilization of the novel feeds on growth, n-3 LC-PUFA utilization and synthesis of Gilthead sea bream will be presented. Our studies showed offspring’s utilization of low n-3 LC-PUFA improved if nutritional clues were supplied during the spawning period, not during early or late larval stages in Gilthead sea bream . Obtained progenies from different fed brood fish showed altered gene expression of lipid metabolism gene such as fads2 , at the larval stage even fed with same commercial diets. This altered metabolism led better utilization of low n-3 LC-PUFA diets at 6 and 18 months of juveniles; we observed lower feed conversion ratios thus higher final weight if fishes were nutritionally challenged with low n-3 LC-PUFA diets in later life stages. Following studies showed the possibility of improving the growth of the offspring by selection of the broodstock by fads2 expression levels at eight-months-old juveniles if fed with low n-3 LC-HUFA diets. On the other hand, our recent studies showed genetic selection of the broodstock can contribute better utilization of the vegetable meal and oil based diets and affects progeny’s performance in later life stages during on-growing. Nutritional programming together with a genetic selection of the broodstock shows excellent possibility further improve the utilization of the low n-3 LC-HUFA diets by the offspring during the on-growing. This novel feeding strategy may lead better utilization of low n-3 LC-HUFA, vegetable-based diets this, in turn, can contribute the sustainable growth of the aquaculture sector.