Native American Tribes and First Nations in the Alaska and British Columbia have a vested interest in protecting traditional natural resources as well as the health of the local community. Regional Tribal networks linked with support from scientist and resource managers have begun detecting harmful algal bloom (HAB) events that pose a human health risk to subsistence and commercial shellfish harvesters. With “eyes on the water” within their communities, Tribes can establish subsistence management plans, integrate aquaculture infrastructure, and continue the cultural importance of shellfish harvesting. Within each regional network, Tribal partners collects weekly samples at key community harvest sites including phytoplankton identification and quantification, salinity, sea and air temperature, whole water for cellular toxin analysis, and shellfish for biotoxins. The data are uploaded to a shared database and are used by resource managers and subsistence harvesters to make informed decisions on harvest timing and risk. Tribal laboratories within each region provide analytical and technical support to each community within the network. By combining weekly phytoplankton observations and shellfish toxin analysis using approved methods developed by NCCOS , Tribal organizations are demonstrating sovereignty through science.